Molecular mechanisms of radiation-induced aging

Abstract

Radiation-induced aging is a complex process that involves multiple molecular mechanisms. One of the primary mechanisms underlying radiation-induced aging is oxidative stress. Exposure to radiation can lead to the generation of reactive oxygen species (ROS), which can cause damage to DNA, proteins, and other cellular components. In addition to these mechanisms, radiation-induced aging can also involve alterations in gene expression, cellular metabolism, and epigenetic modifications. These changes can affect the function of various cellular pathways and contribute to the aging process. Understanding the molecular mechanisms of radiation-induced aging is critical for developing strategies to mitigate its effects. Potential interventions include targeting oxidative stress, promoting DNA repair, altering the epigenetic landscape and modulating cellular metabolism. However, further research is needed to fully elucidate the complex molecular pathways involved in radiation-induced aging and identify effective therapeutic approaches. In general, the molecular mechanisms of radiation's impact on aging discussed in this review provide a new perspective on radiation-induced aging and identify new targets for intervention.