Investigation of the effect of agomelatine on cellular and humoral immunity in mice

Abstract

Agomelatine has primarily been described as an antidepressant drug for laborartory animals. In the present
study, agomelatine showed an overall stimulatory effect on the specific, as well as on non-specific immune functions of mice. Stimulatory effects were observed at 25 mg/kg. Administration of agomelatine in human beings is simple as it is available in the dosage form. The general immunomodulatory effects of agomelatine need further investigation for its use in the cases of clinical immunostimulation and in order to understand the
precise mechanism of action for the stimulatory effect of the drug. The present result suggests that agomelatine
may stimulate both the cellular and humoral immunity. Effects were evaluated at different doses of 1, 5 and 25 mg/kg using various parameters such as effect on hematological parameters. The results were further utilized to evaluate the activity on the cellular and humoral branches of immunity.