New polymer complexes of isonicotinic acid hydrazide with anti-tuberculosis and immunostimulating effects

Abstract

Tuberculosis refers to one of the socially significant diseases. The scientific literature justifies the feasibility
of using polymer matrices to immobilize protuberculous drugs, which contributes to the completion of phagocytosis. Comparative study of antituberculosis activity of analogues of isonicotinic acid hydrazide condensate in treatment of experimental tuberculosis in mice was carried out. The effectiveness of using chlorohydroxychitosan complex with 1-isonicotinyl-2-D-glucosyl hydrosone with included Co2 + has been established in comparison with chitosan-cobalt-1-isonicotinyl-2-D-glucosyl hydrosone in treating experimental tuberculosis. Immunostimulatory activity of polymer metal complex comparable to chitosan-cobalt-1-isonicotinyl-2-D-glucosyl hydrosone complex was revealed. The results obtained in the experiment
can be used in the development of modern, treatment methods for tuberculosis.